Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response

Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response

Granulomas are important immunological structures in the host defense against the fungus Paracoccidioides brasiliensis, the main etiologic agent of Paracoccidioidomycosis (PCM), a granulomatous systemic mycosis endemic in Latin America. We have performed transcriptional and proteomic studies of yeas...

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Main Authors: Bruno Montanari Borges, Rafael Berton Correia Ramos, Nycolas Willian Preite, Valéria de Lima Kaminski, Patrícia Alves de Castro, Maurício Camacho, Marina Ferreira Maximo, Taicia Pacheco Fill, Vera Lúcia Garcia Calich, Aimee M. Traynor, Özlem Sarikaya-Bayram, Sean Doyle, Özgür Bayram, Claudia Barbosa Ladeira de Campos, André Zelanis, Gustavo H. Goldman, Flávio Vieira Loures
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
paracoccidioidomycosis
granuloma
transcriptomic
proteomic
fungal infection
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1268959/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1268959/full

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