Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a]
Apolipoprotein [a] (apo[a]) gene size is a major predictor of lipoprotein [a] level. To determine genetic predictors of allele-specific apo[a] levels beyond gene size, we evaluated the upstream C/T and pentanucleotide repeat (PNR) polymorphisms. We determined apo[a] sizes, allele-specific apo[a] lev...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-05-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520332466 |
| _version_ | 1818732272514236416 |
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| author | Jill Rubin Han Jo Kim Thomas A. Pearson Steve Holleran Rajasekhar Ramakrishnan Lars Berglund |
| author_facet | Jill Rubin Han Jo Kim Thomas A. Pearson Steve Holleran Rajasekhar Ramakrishnan Lars Berglund |
| author_sort | Jill Rubin |
| collection | DOAJ |
| description | Apolipoprotein [a] (apo[a]) gene size is a major predictor of lipoprotein [a] level. To determine genetic predictors of allele-specific apo[a] levels beyond gene size, we evaluated the upstream C/T and pentanucleotide repeat (PNR) polymorphisms. We determined apo[a] sizes, allele-specific apo[a] levels, and C/T and PNR in 215 Caucasians and 139 African Americans. For Caucasians, apo[a] size affected allele-specific levels substantially greater in subjects with apo[a] < 24 K4; for African Americans, the size effect was smaller than in Caucasians, <24 K4, but did not decrease at higher repeats. In both groups, the level decreased with increasing size of the other allele. Controlling for apo[a] sizes, PNR decreased allele-specific apo[a] levels in Caucasians with increasing PNR > 8. In a multiple regression model, apo[a] allele size and size and expression of the other apo[a] allele (and PNR > 8 for Caucasians) significantly predicted allele-specific apo[a] levels. For a common PNR 8 allele, predicted values were similar in the two ethnicities for small size apo[a]. Allele-specific apo[a] levels were influenced by the other allele size and expression. Observed differences between Caucasians and African Americans in allele-specific apo[a] levels were explained for small apo[a] sizes by the other allele size and PNR; the ethnicity differences remain unexplained for larger sizes. |
| first_indexed | 2024-12-17T23:30:56Z |
| format | Article |
| id | doaj.art-68abd015d27b4bbf9d2ea1327e103b9a |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T23:30:56Z |
| publishDate | 2006-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-68abd015d27b4bbf9d2ea1327e103b9a2022-12-21T21:28:39ZengElsevierJournal of Lipid Research0022-22752006-05-01475982989Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a]Jill Rubin0Han Jo Kim1Thomas A. Pearson2Steve Holleran3Rajasekhar Ramakrishnan4Lars Berglund5Department of Medicine, Columbia University, New York, NYDepartment of Medicine, Columbia University, New York, NYDepartment of Community and Family Medicine, University of Rochester, Rochester, NYDepartment of Pediatrics, Columbia University, New York, NYDepartment of Pediatrics, Columbia University, New York, NYDepartment of Medicine, Columbia University, New York, NY; Department of Medicine, University of California Davis, Davis, CA; Department of Veterans Affairs Northern California Health Care System, Sacramento, CAApolipoprotein [a] (apo[a]) gene size is a major predictor of lipoprotein [a] level. To determine genetic predictors of allele-specific apo[a] levels beyond gene size, we evaluated the upstream C/T and pentanucleotide repeat (PNR) polymorphisms. We determined apo[a] sizes, allele-specific apo[a] levels, and C/T and PNR in 215 Caucasians and 139 African Americans. For Caucasians, apo[a] size affected allele-specific levels substantially greater in subjects with apo[a] < 24 K4; for African Americans, the size effect was smaller than in Caucasians, <24 K4, but did not decrease at higher repeats. In both groups, the level decreased with increasing size of the other allele. Controlling for apo[a] sizes, PNR decreased allele-specific apo[a] levels in Caucasians with increasing PNR > 8. In a multiple regression model, apo[a] allele size and size and expression of the other apo[a] allele (and PNR > 8 for Caucasians) significantly predicted allele-specific apo[a] levels. For a common PNR 8 allele, predicted values were similar in the two ethnicities for small size apo[a]. Allele-specific apo[a] levels were influenced by the other allele size and expression. Observed differences between Caucasians and African Americans in allele-specific apo[a] levels were explained for small apo[a] sizes by the other allele size and PNR; the ethnicity differences remain unexplained for larger sizes.http://www.sciencedirect.com/science/article/pii/S0022227520332466lipoprotein [a]African Americansgenotypingpolymorphismapolipoprotein [a]pentanucleotide repeat |
| spellingShingle | Jill Rubin Han Jo Kim Thomas A. Pearson Steve Holleran Rajasekhar Ramakrishnan Lars Berglund Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a] Journal of Lipid Research lipoprotein [a] African Americans genotyping polymorphism apolipoprotein [a] pentanucleotide repeat |
| title | Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a] |
| title_full | Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a] |
| title_fullStr | Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a] |
| title_full_unstemmed | Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a] |
| title_short | Apo[a] size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a] |
| title_sort | apo a size and pnr explain african american caucasian differences in allele specific apo a levels for small but not large apo a |
| topic | lipoprotein [a] African Americans genotyping polymorphism apolipoprotein [a] pentanucleotide repeat |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520332466 |
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