The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

Abstract Background Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. Despite advances in d...

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Bibliographic Details
Main Authors: Yue Zhao, Ji Zhu, Bowen Shi, Xinyu Wang, Qijue Lu, Chunguang Li, Hezhong Chen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
OV6
Lymphoid enhancer-binding factor 1 (LEF1)
Esophageal squamous cell carcinoma (ESCC)
Prognosis
CSC-like phenotype
Online Access:http://link.springer.com/article/10.1186/s13046-019-1296-7

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http://link.springer.com/article/10.1186/s13046-019-1296-7

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