Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway

Argatroban promotes recovery of spinal cord injury by inhibiting the PAR1/JAK2/STAT3 signaling pathway

Argatroban is a synthetic thrombin inhibitor approved by U.S. Food and Drug Administration for the treatment of thrombosis. However, whether it plays a role in the repair of spinal cord injury is unknown. In this study, we established a rat model of T10 moderate spinal cord injury using an NYU Impac...

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Bibliographic Details
Main Authors: Chenxi Zhao, Tiangang Zhou, Ming Li, Jie Liu, Xiaoqing Zhao, Yilin Pang, Xinjie Liu, Jiawei Zhang, Lei Ma, Wenxiang Li, Xue Yao, Shiqing Feng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
argatroban; astrogliosis; jak/stat signaling pathway; protease-activated receptor-1; spinal cord injury; thrombin; vimentin
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=434;epage=439;aulast=

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=2;spage=434;epage=439;aulast=

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