Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa

Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa

Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited skin disease characterized by defects in type VII collagen leading to a range of fibrotic pathologies resulting from skin fragility, aberrant wound healing, and altered dermal fibroblast physiology. Using a novel in vitro...

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Bibliographic Details
Main Authors: Grace Tartaglia, Ignacia Fuentes, Neil Patel, Abigail Varughese, Lauren E Israel, Pyung Hun Park, Michael H Alexander, Shiv Poojan, Qingqing Cao, Brenda Solomon, Zachary M Padron, Jonathan A Dyer, Jemima E Mellerio, John A McGrath, Francis Palisson, Julio Salas-Alanis, Lin Han, Andrew P South
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:EMBO Molecular Medicine
Subjects:
Fibrosis
Collagen
Recessive Dystrophic Epidermolysis Bullosa
Drug Repurposing
Antivirals
Online Access:https://doi.org/10.1038/s44321-024-00048-8

Internet

https://doi.org/10.1038/s44321-024-00048-8

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