Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines
A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2014-09-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.214 |
| _version_ | 1819068738553511936 |
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| author | Praveen Reddy Adiyala D. Chandrasekhar Jeevak Sopanrao Kapure Chada Narsimha Reddy Ram Awatar Maurya |
| author_facet | Praveen Reddy Adiyala D. Chandrasekhar Jeevak Sopanrao Kapure Chada Narsimha Reddy Ram Awatar Maurya |
| author_sort | Praveen Reddy Adiyala |
| collection | DOAJ |
| description | A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields. |
| first_indexed | 2024-12-21T16:38:55Z |
| format | Article |
| id | doaj.art-68b36474202d46acad449d88b548d0d8 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-21T16:38:55Z |
| publishDate | 2014-09-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-68b36474202d46acad449d88b548d0d82022-12-21T18:57:09ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-09-011012065207010.3762/bjoc.10.2141860-5397-10-214Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and aminesPraveen Reddy Adiyala0D. Chandrasekhar1Jeevak Sopanrao Kapure2Chada Narsimha Reddy3Ram Awatar Maurya4Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, IndiaDivision of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, IndiaDivision of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, IndiaDivision of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, IndiaDivision of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, IndiaA facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.https://doi.org/10.3762/bjoc.10.214α-amino amidinesiodineisocyanidemulticomponent reactionUgi reaction |
| spellingShingle | Praveen Reddy Adiyala D. Chandrasekhar Jeevak Sopanrao Kapure Chada Narsimha Reddy Ram Awatar Maurya Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines Beilstein Journal of Organic Chemistry α-amino amidines iodine isocyanide multicomponent reaction Ugi reaction |
| title | Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines |
| title_full | Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines |
| title_fullStr | Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines |
| title_full_unstemmed | Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines |
| title_short | Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines |
| title_sort | synthesis of α amino amidines through molecular iodine catalyzed three component coupling of isocyanides aldehydes and amines |
| topic | α-amino amidines iodine isocyanide multicomponent reaction Ugi reaction |
| url | https://doi.org/10.3762/bjoc.10.214 |
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