Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes

Where and when to start: Regulating DNA replication origin activity in eukaryotic genomes

ABSTRACTIn eukaryotic genomes, hundreds to thousands of potential start sites of DNA replication named origins are dispersed across each of the linear chromosomes. During S-phase, only a subset of origins is selected in a stochastic manner to assemble bidirectional replication forks and initiate DNA...

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Bibliographic Details
Main Authors: Clare S.K. Lee, Matthias Weiβ, Stephan Hamperl
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Nucleus
Subjects:
3D Genome Organization
chromatin structure
DNA replication
origin clustering
origins of replication
replication timing
Online Access:https://www.tandfonline.com/doi/10.1080/19491034.2023.2229642

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https://www.tandfonline.com/doi/10.1080/19491034.2023.2229642

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