<i>n</i>-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway

<i>n</i>-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway

Spinocerebellar ataxia type 3 (SCA3), a hereditary and lethal neurodegenerative disease, is attributed to the abnormal accumulation of undegradable polyglutamine (polyQ), which is encoded by mutated ataxin-3 gene (<i>ATXN3</i>). The toxic fragments processed from mutant <i>ATXN3<...

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Bibliographic Details
Main Authors: Jui-Hao Lee, Si-Yin Lin, Jen-Wei Liu, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
MJD
SCA3
Purkinje cell
PolyQ
atxain-3
toxic fragment
Online Access:https://www.mdpi.com/1422-0067/22/12/6339

Internet

https://www.mdpi.com/1422-0067/22/12/6339

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