<i>n</i>-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
Spinocerebellar ataxia type 3 (SCA3), a hereditary and lethal neurodegenerative disease, is attributed to the abnormal accumulation of undegradable polyglutamine (polyQ), which is encoded by mutated ataxin-3 gene (<i>ATXN3</i>). The toxic fragments processed from mutant <i>ATXN3<...
Main Authors: | Jui-Hao Lee, Si-Yin Lin, Jen-Wei Liu, Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/12/6339 |
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