Murine CD4+ T cell responses are inhibited by cytotoxic T cell-mediated killing of dendritic cells and are restored by antigen transfer.

Murine CD4+ T cell responses are inhibited by cytotoxic T cell-mediated killing of dendritic cells and are restored by antigen transfer.

Cytotoxic T lymphocytes (CTL) provide protection against pathogens and tumors. In addition, experiments in mouse models have shown that CTL can also kill antigen-presenting dendritic cells (DC), reducing their ability to activate primary and secondary CD8(+) T cell responses. In contrast, the effect...

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Bibliographic Details
Main Authors: Joel Zhi-Iong Ma, So Nai Lim, Jim Shixiang Qin, Jianping Yang, Noriyuki Enomoto, Christiane Ruedl, Franca Ronchese
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3359309?pdf=render

Internet

http://europepmc.org/articles/PMC3359309?pdf=render

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