Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice

Immune progenitor cells differentiate in bone marrow (BM) and then migrate to tissues. HIV-1 infects multiple BM cell types, but virus dissemination within BM has been poorly understood. We used light microscopy and electron tomography to elucidate mechanisms of HIV-1 dissemination within BM of HIV-...

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Bibliographic Details
Main Authors: Mark S Ladinsky, Wannisa Khamaikawin, Yujin Jung, Samantha Lin, Jennifer Lam, Dong Sung An, Pamela J Bjorkman, Collin Kieffer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
HIV-1
light sheet microscopy
humanized mouse
electron tomography
tissue clearing
Online Access:https://elifesciences.org/articles/46916

Internet

https://elifesciences.org/articles/46916

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