Histamine-modulated wettability switching in G-protein-coupled receptor inspired nanochannel for potential drug screening and biosensing

Abstract Histamine receptor, one typical G-protein-coupled receptor (GPCR), can be activated by histamine and form the most important drug targets involved in allergy and reflux diseases. Here, we report an artificial model to mimic the wettability-induced activation of natural GPCRs via histamine-m...

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Bibliographic Details
Main Authors: Qi Zhao, Xu-Qin Ran, Zhu-Ying Yan, Hai-Long Qian, Xiu-Ping Yan
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57064-6