Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis

Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis

Achieving immunoregulation via in vivo expansion of Foxp3+ regulatory CD4+ T cells (Treg) remains challenging. We have shown that mobilization confers to multipotent hematopoietic progenitors (MPPs) the capacity to enhance Treg proliferation. Transcriptomic analysis of Tregs co-cultured with MPPs re...

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Bibliographic Details
Main Authors: Sarantis Korniotis, Maud D’Aveni, Sébastien Hergalant, Hélène Letscher, Emmanuel Tejerina, Pauline Gastineau, Viviane A. Agbogan, Christophe Gras, Guillemette Fouquet, Julien Rossignol, Jean-Claude Chèvre, Nicolas Cagnard, Marie-Thérèse Rubio, Olivier Hermine, Flora Zavala
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
transcriptome
multiple sclerosis
IL-1β
expansion
stability
Tregs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607175/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.607175/full

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