LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM

LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM

Abstract Background Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, and chemoresistance is a major obstacle in its treatment. Despite advances in therapy, the molecular mechanism underlying chemoresistance in CRC is not fully understood. Recent studies have implicated th...

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Bibliographic Details
Main Authors: Zehua Bian, Fan Yang, Peiwen Xu, Ge Gao, Chunyu Yang, Yulin Cao, Surui Yao, Xue Wang, Yuan Yin, Bojian Fei, Zhaohui Huang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
lncRNA
Chemoresistance
Aerobic glycolysis
Alternative splicing
Online Access:https://doi.org/10.1186/s12943-024-01939-7

Internet

https://doi.org/10.1186/s12943-024-01939-7

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