Modeling Blast Crisis Using Mutagenized Chronic Myeloid Leukemia-Derived Induced Pluripotent Stem Cells (iPSCs)

Modeling Blast Crisis Using Mutagenized Chronic Myeloid Leukemia-Derived Induced Pluripotent Stem Cells (iPSCs)

Purpose: To model CML progression in vitro and generate a blast crisis (BC-CML) model in vitro in order to identify new targets. Methods: Three different CML-derived iPSC lines were mutagenized with the alkylating agent ENU on a daily basis for 60 days. Cells were analyzed at D12 of hematopoietic di...

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Bibliographic Details
Main Authors: Jusuf Imeri, Christophe Desterke, Paul Marcoux, Gladys Telliam, Safa Sanekli, Sylvain Barreau, Yucel Erbilgin, Theodoros Latsis, Patricia Hugues, Nathalie Sorel, Emilie Cayssials, Jean-Claude Chomel, Annelise Bennaceur-Griscelli, Ali G. Turhan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
iPSC
blast crisis CML
CML modeling
single-cell transcriptomics
CD25
Online Access:https://www.mdpi.com/2073-4409/12/4/598

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https://www.mdpi.com/2073-4409/12/4/598

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