FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis

FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis

Abstract FGF19 hormone has pleiotropic metabolic functions, including the modulation of insulin sensitivity, glucose/lipid metabolism and energy homeostasis. On top of its physiological metabolic role, FGF19 has been identified as a potentially targetable oncogenic driver, notably in hepatocellular...

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Bibliographic Details
Main Authors: José Ursic-Bedoya, Guillaume Desandré, Carine Chavey, Pauline Marie, Arnaud Polizzi, Benjamin Rivière, Hervé Guillou, Eric Assenat, Urszula Hibner, Damien Gregoire
Format: Article
Language:English
Published: Springer Nature 2024-01-01
Series:EMBO Molecular Medicine
Subjects:
Aldafermin (NGM282)
FGF19-15
Hydrodynamic Injections
Liver Cancer
Oncogenic Cooperation
Online Access:https://doi.org/10.1038/s44321-023-00021-x

Internet

https://doi.org/10.1038/s44321-023-00021-x

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