Beneficial effect of temporary methotrexate interruption on B and T cell responses upon SARS-CoV-2 vaccination in patients with rheumatoid arthritis or psoriatic arthritis

Abstract B and T cell responses were evaluated in patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) after 1 or 2 weeks of methotrexate (MTX) withdrawal following each COVID-19 vaccine dose and compared with those who maintained MTX. Adult RA and PsA patients treated with MTX were...

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Main Authors: Pedro Martínez-Fleta, Esther F. Vicente-Rabaneda, Ana Triguero-Martínez, Emilia Roy-Vallejo, Miren Uriarte-Ecenarro, Francisco Gutiérrez-Rodríguez, Patricia Quiroga-Colina, Ana Romero-Robles, Nuria Montes, Noelia García-Castañeda, Gina P. Mejía-Abril, Jesús A. García-Vadillo, Irene Llorente-Cubas, José R. Villagrasa, José M. Serra López-Matencio, Julio Ancochea, Ana Urzainqui, Laura Esparcia-Pinedo, Arantzazu Alfranca, Hortensia de la Fuente, Rosario García-Vicuña, Francisco Sánchez-Madrid, Isidoro González-Álvaro, Santos Castañeda
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-00805-3