Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation

Early Pregnancy Exposure to Ambient Air Pollution among Late-Onset Preeclamptic Cases Is Associated with Placental DNA Hypomethylation of Specific Genes and Slower Placental Maturation

Exposure to ambient air pollution during pregnancy has been associated with an increased risk of preeclampsia (PE). Some suggested mechanisms behind this association are changes in placental DNA methylation and gene expression. The objective of this study was to identify how early pregnancy exposure...

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Bibliographic Details
Main Authors: Karin Engström, Yumjirmaa Mandakh, Lana Garmire, Zahra Masoumi, Christina Isaxon, Ebba Malmqvist, Lena Erlandsson, Stefan R. Hansson
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Toxics
Subjects:
ambient air pollution
preeclampsia
global DNA methylation
RNA sequencing
epigenetic age
placenta
Online Access:https://www.mdpi.com/2305-6304/9/12/338

Internet

https://www.mdpi.com/2305-6304/9/12/338

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