Pharmacological Inhibition of Core Regulatory Circuitry Liquid–liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma

Pharmacological Inhibition of Core Regulatory Circuitry Liquid–liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma

Abstract Liquid–liquid phase‐separated (LLPS) transcriptional factor assemblies at super‐enhancers (SEs) provide a conceptual framework for underlying transcriptional control in mammal cells. However, the mechanistic understanding of LLPS in aberrant transcription driven by dysregulation of SEs in h...

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Bibliographic Details
Main Authors: Bing Lu, Changye Zou, Meiling Yang, Yangyang He, Jincan He, Chuanxia Zhang, Siyun Chen, Jiaming Yu, Kilia Yun Liu, Qi Cao, Wei Zhao
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Advanced Science
Subjects:
core regulatory circuitry
HOXB8
liquid–liquid phase separation
osteosarcoma
super‐enhancer
Online Access:https://doi.org/10.1002/advs.202101895

Internet

https://doi.org/10.1002/advs.202101895

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