Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture

Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture

Abstract The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytokines in response to TNF-α. Furthermore, studies have...

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Main Authors: Vinicius Wanatable Nakao, Caio Henrique Yokowama Mazucanti, Larissa de Sá Lima, Paloma Segura de Mello, Natacha Medeiros de Souza Port’s, Paula Fernanda Kinoshita, Jacqueline Alves Leite, Elisa Mitiko Kawamoto, Cristoforo Scavone
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-21132-4

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https://doi.org/10.1038/s41598-022-21132-4

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