Identification of a novel class of cyclic penta-peptides against hepatitis C virus as p7 channel blockers

Identification of a novel class of cyclic penta-peptides against hepatitis C virus as p7 channel blockers

The hepatitis C virus (HCV) p7 viroporin protein is essential for viral assembly and release, suggesting its unrealised potential as a target for HCV interventions. Several classes of small molecules that can inhibit p7 through allosteric mechanisms have shown low efficacy. Here, we used a high thro...

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Bibliographic Details
Main Authors: Shukun Wei, Chaolun Liu, Lingyu Du, Bin Wu, Jin Zhong, Yimin Tong, Shuqing Wang, Bo OuYang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Drug design
Cyclic penta-peptide
Channel blocker
P7
HCV
NMR
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004834

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022004834

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