ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

Genetic co-depletion of the actin-severing proteins ADF and CFL1 triggers catastrophic loss of adult homeostasis in multiple tissues. There is impaired cell-cell adhesion in skin keratinocytes with dysregulation of E-cadherin, hyperproliferation of differentiated cells, and ultimately apoptosis. Mec...

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Bibliographic Details
Main Authors: Georgios Kanellos, Jing Zhou, Hitesh Patel, Rachel A. Ridgway, David Huels, Christine B. Gurniak, Emma Sandilands, Neil O. Carragher, Owen J. Sansom, Walter Witke, Valerie G. Brunton, Margaret C. Frame
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715012450

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http://www.sciencedirect.com/science/article/pii/S2211124715012450

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