Suppression of Pain in the Late Phase of Chronic Trigeminal Neuropathic Pain Failed to Rescue the Decision-Making Deficits in Rats

Suppression of Pain in the Late Phase of Chronic Trigeminal Neuropathic Pain Failed to Rescue the Decision-Making Deficits in Rats

Trigeminal neuropathic pain (TNP) led to vital cognitive functional deficits such as impaired decision-making abilities in a rat gambling task. Chronic TNP caused hypomyelination in the anterior cingulate cortex (ACC) associated with decreased synchronization between ACC spikes and basal lateral amy...

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Bibliographic Details
Main Authors: Suresh Kanna Murugappan, Li Xie, Heung Yan Wong, Zafar Iqbal, Zhuogui Lei, Aruna Surendran Ramkrishnan, Ying Li
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
anterior cingulate cortex
trigeminal neuropathic pain
decision making
early or late phase
tetrodotoxin
synaptic plasticity
Online Access:https://www.mdpi.com/1422-0067/22/15/7846

Internet

https://www.mdpi.com/1422-0067/22/15/7846

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