Atom-economic catalytic amide synthesis from amines and carboxylic acids activated in situ with acetylenes
Amide formation is a ubiquitous reaction in organic chemistry, but suffers from the problem of generating large amounts of waste. Here, the authors report a catalytic amide synthesis by the ruthenium catalysed addition of carboxylic acids to acetylenes, followed by reaction with primary or secondary...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11732 |