MiR-148a-3p within HucMSC-Derived Extracellular Vesicles Suppresses Hsp90b1 to Prevent Fibroblast Collagen Synthesis and Secretion in Silica-Induced Pulmonary Fibrosis

MiR-148a-3p within HucMSC-Derived Extracellular Vesicles Suppresses Hsp90b1 to Prevent Fibroblast Collagen Synthesis and Secretion in Silica-Induced Pulmonary Fibrosis

Silicosis is a fatal occupational respiratory disease caused by the prolonged inhalation of respirable silica. The core event of silicosis is the heightened activity of fibroblasts, which excessively synthesize extracellular matrix (ECM) proteins. Our previous studies have highlighted that human umb...

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Bibliographic Details
Main Authors: Qiyue Jiang, Jing Zhao, Qiyue Jia, Hongwei Wang, Wenming Xue, Fuao Ning, Jiaxin Wang, Yan Wang, Zhonghui Zhu, Lin Tian
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
silica
pulmonary fibrosis
extracellular vesicles
HucMSCs
fibroblasts
MiR-148a-3p
Online Access:https://www.mdpi.com/1422-0067/24/19/14477

Internet

https://www.mdpi.com/1422-0067/24/19/14477

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