Flavonoid Derivatives as Potential Cholinesterase Inhibitors in Scopolamine-Induced Amnesic Mice: An In Vitro, In Vivo and Integrated Computational Approach

Flavonoid Derivatives as Potential Cholinesterase Inhibitors in Scopolamine-Induced Amnesic Mice: An In Vitro, In Vivo and Integrated Computational Approach

Flavonoids are one of the most exciting types of phenolic compounds with a wide range of bioactive benefits. A series of flavone derivatives (<b>F1</b>–<b>F5</b>) were previously synthesized from substituted O-hydroxy acetophenone and substituted chloro-benzaldehydes. The tit...

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Bibliographic Details
Main Authors: Fakhria A. Al-Joufi, Syed Wadood Ali Shah, Mohammad Shoaib, Mehreen Ghias, Shafiullah, Atif Ali Khan Khalil, Syed Babar Jamal, Syed Muhammad Hassan Shah, Muhammad Zahoor
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Brain Sciences
Subjects:
flavones
enzyme inhibition
docking
Alzheimer’s disease
AChE
nootropic agents
Online Access:https://www.mdpi.com/2076-3425/12/6/731

Internet

https://www.mdpi.com/2076-3425/12/6/731

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