Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer’s Disease and Control Mice

Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer’s Disease and Control Mice

Apolipoprotein ε4 (APOE)4 is a strong risk factor for the development of Alzheimer’s disease (AD) and aberrant sphingolipid levels have been implicated in AD. We tested the hypothesis that the APOE4 genotype affects brain sphingolipid levels in AD. Seven ceramides and sphingosine-1-phosphate (S1P) w...

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Bibliographic Details
Main Authors: Sandra den Hoedt, Simone M. Crivelli, Frank P. J. Leijten, Mario Losen, Jo A. A. Stevens, Marina Mané-Damas, Helga E. de Vries, Jochen Walter, Mina Mirzaian, Eric J. G. Sijbrands, Johannes M. F. G. Aerts, Adrie J. M. Verhoeven, Pilar Martinez-Martinez, Monique T. Mulder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
ceramide
S1P
apolipoprotein E4
Alzheimer’s disease
aging
sex differences
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.765252/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.765252/full

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