Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system

Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system

Abstract The glymphatic system plays a key role in the clearance of waste from the parenchyma, and its dysfunction has been associated with the pathogenesis of Alzheimer's disease (AD). However, questions remain regarding its complete mechanisms. Here, we report that efflux of cerebrospinal flu...

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Bibliographic Details
Main Authors: Yaqiong Dong, Ting Xu, Lan Yuan, Yahan Wang, Siwang Yu, Zhi Wang, Shizhu Chen, Chunhua Chen, Weijiang He, Tessandra Stewart, Weiguang Zhang, Xiaoda Yang
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Exploration
Subjects:
Aβ clearance
brain drainage pathway
dynamic asymmetric pores
perivascular space dilation
tight junctions
Online Access:https://doi.org/10.1002/EXP.20230029

Internet

https://doi.org/10.1002/EXP.20230029

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