The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis

The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis

Mitochondria deserve special attention as sensors of cellular energy homeostasis and metabolic state. Moreover, mitochondria integrate intra- and extra-cellular signals to determine appropriate cellular responses that range from proliferation to cell death. In autoimmunity, as in other inflammatory...

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Bibliographic Details
Main Authors: Mykolas Bendorius, Indira Neeli, Fengjuan Wang, Srinivasa Reddy Bonam, Eszter Dombi, Nelly Buron, Annie Borgne-Sanchez, Joanna Poulton, Marko Radic, Sylviane Muller
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
NETosis
autophagy
mitochondrion
systemic lupus erythematosus
neuroinflammation
P140 peptide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02158/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02158/full

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