Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Glutathione peroxidase 4 (GPX4) plays an important effect on ferroptosis. Down-regulating the expression of GPX4 mRNA can decrease the content of GPX4. In this work, a gold nanoflare (AuNF) probe loaded with anti-sense sequences targeting for GPX4 mRNA was designed to monitor and down-regulate intra...

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Bibliographic Details
Main Authors: Xiaoyan Liu, Qiangqiang Yang, Yanan Sui, Qiaoli Yue, Shuqing Yan, Chuan Li, Min Hong
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biosensors
Subjects:
ferroptosis
GPX4 mRNA
AuNF probe
Online Access:https://www.mdpi.com/2079-6374/12/12/1178

Internet

https://www.mdpi.com/2079-6374/12/12/1178

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