Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Abstract Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer‐associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a...

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Bibliographic Details
Main Authors: Sara Chiappalupi, Guglielmo Sorci, Aleksandra Vukasinovic, Laura Salvadori, Roberta Sagheddu, Dario Coletti, Giorgia Renga, Luigina Romani, Rosario Donato, Francesca Riuzzi
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Cancer cachexia
RAGE
Inflammation
Muscle atrophy
S100B
HMGB1
Online Access:https://doi.org/10.1002/jcsm.12561

Internet

https://doi.org/10.1002/jcsm.12561

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