Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system.

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system.

Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity. Humans with mutations in the MC4R experience an increase in lean mass. However, the simultaneous accrual of fat mass in s...

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Bibliographic Details
Main Authors: Theodore P Braun, Benjamin Orwoll, Xinxia Zhu, Peter R Levasseur, Marek Szumowski, My Linh T Nguyen, Mary L Bouxsein, Robert F Klein, Daniel L Marks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407101?pdf=render

Internet

http://europepmc.org/articles/PMC3407101?pdf=render

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