The protective effects of sesamol and/or the probiotic, Lactobacillus rhamnosus, against aluminum chloride-induced neurotoxicity and hepatotoxicity in rats: Modulation of Wnt/β-catenin/GSK-3β, JAK-2/STAT-3, PPAR-γ, inflammatory, and apoptotic pathways

The protective effects of sesamol and/or the probiotic, Lactobacillus rhamnosus, against aluminum chloride-induced neurotoxicity and hepatotoxicity in rats: Modulation of Wnt/β-catenin/GSK-3β, JAK-2/STAT-3, PPAR-γ, inflammatory, and apoptotic pathways

Introduction: Aluminium (Al) is accumulated in the brain causing neurotoxicity and neurodegenerative disease like Alzheimer's disease (AD), multiple sclerosis, autism and epilepsy. Hence, attenuation of Al-induced neurotoxicity has become a “hot topic“ in looking for an intervention that slow d...

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Main Authors: Karema Abu-Elfotuh, Heba Mohammed Refat M. Selim, Omnia Karem M. Riad, Ahmed M. E. Hamdan, Soha Osama Hassanin, Asmaa F. Sharif, Nouran Magdy Moustafa, Ayah M.H. Gowifel, Marwa Y. A. Mohamed, Ahmed M. Atwa, Sameh S. Zaghlool, Mahmoud Nour El-Din
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
AlCl3
JAK-2/STAT-3
Lactobacillus rhamnosus
neurotoxicity
PPAR-γ
probiotic
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1208252/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1208252/full

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