5-(<i>N</i>-Trifluoromethylcarboxy)aminouracil as a Potential DNA Radiosensitizer and Its Radiochemical Conversion into <i>N</i>-Uracil-5-yloxamic Acid

5-(<i>N</i>-Trifluoromethylcarboxy)aminouracil as a Potential DNA Radiosensitizer and Its Radiochemical Conversion into <i>N</i>-Uracil-5-yloxamic Acid

Hypoxia—a hallmark of solid tumors—dramatically impairs radiotherapy, one of the most common anticancer modalities. The adverse effect of the low-oxygen state can be eliminated by the concomitant use of a hypoxic cell radiosensitizer. In the present paper, we show that 5-(<i>N</i>-triflu...

Full description

Bibliographic Details
Main Authors: Paulina Spisz, Witold Kozak, Lidia Chomicz-Mańka, Samanta Makurat, Karina Falkiewicz, Artur Sikorski, Anna Czaja, Janusz Rak, Magdalena Zdrowowicz
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
radiosensitizer
uracil derivatives
modified nucleobases
electron-induced degradation
DFT calculations
Online Access:https://www.mdpi.com/1422-0067/21/17/6352

Internet

https://www.mdpi.com/1422-0067/21/17/6352

Similar Items