Sequential gene expression analysis of myelodysplastic syndrome transformation identifies HOXB3 and HOXB7 as the novel targets for mesenchymal cells in disease

Sequential gene expression analysis of myelodysplastic syndrome transformation identifies HOXB3 and HOXB7 as the novel targets for mesenchymal cells in disease

Abstract Background Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of MDS patients, it is difficult to find common targets in studies with li...

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Bibliographic Details
Main Authors: Chunlai Yin, Yanqi Li, Cheng Zhang, Shizhu Zang, Zilong Wang, Xue Yan, Tonghui Ma, Xia Li, Weiping Li
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Cancer
Subjects:
Myelodysplastic syndromes
Mesenchymal stem cells
Gene expression profiling
Targets
HOXB3
HOXB7
Online Access:https://doi.org/10.1186/s12885-024-11859-w

Internet

https://doi.org/10.1186/s12885-024-11859-w

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