The MASTL-ENSA-PP2A/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma

The MASTL-ENSA-PP2A/B55 axis modulates cisplatin resistance in oral squamous cell carcinoma

Platinum-based chemotherapy is the standard first-line treatment for oral squamous cell carcinoma (OSCC) that is inoperable, recurrent, or metastatic. Platinum sensitivity is a major determinant of patient survival in advanced OSCC. Here, we investigated the involvement of MASTL, a cell cycle kinase...

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Bibliographic Details
Main Authors: Odjo G. Gouttia, Jing Zhao, Yanqiu Li, Mackenzie J. Zwiener, Ling Wang, Gregory G. Oakley, Aimin Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MASTL
greatwall kinase
DNA damage
oral cancer
cisplatin
OSCC
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.904719/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.904719/full

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