Zebrafish small molecule screens: Taking the phenotypic plunge
Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alterna...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037016300447 |
| _version_ | 1818595640727306240 |
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| author | Charles H. Williams Charles C. Hong |
| author_facet | Charles H. Williams Charles C. Hong |
| author_sort | Charles H. Williams |
| collection | DOAJ |
| description | Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alternative approach to early drug discovery. We discuss the various model organisms used in phenotypic screens, with particular focus on zebrafish, which has emerged as a leading model of in vivo phenotypic screens. Additionally, we anticipate therapeutic opportunities, particularly in orphan disease space, in the context of rapid advances in human Mendelian genetics, electronic health record (EHR)-enabled genome–phenome associations, and genome editing. |
| first_indexed | 2024-12-16T11:19:14Z |
| format | Article |
| id | doaj.art-68f88a35598449bead6cb7fc71ea72bb |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-16T11:19:14Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-68f88a35598449bead6cb7fc71ea72bb2022-12-21T22:33:30ZengElsevierComputational and Structural Biotechnology Journal2001-03702016-01-0114C35035610.1016/j.csbj.2016.09.001Zebrafish small molecule screens: Taking the phenotypic plungeCharles H. Williams0Charles C. Hong1Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USATarget based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this reductionist approach is being questioned in light of declines in pharmaceutical R & D efficiency. In recent years, phenotypic screens have gained increasing acceptance as a complementary/alternative approach to early drug discovery. We discuss the various model organisms used in phenotypic screens, with particular focus on zebrafish, which has emerged as a leading model of in vivo phenotypic screens. Additionally, we anticipate therapeutic opportunities, particularly in orphan disease space, in the context of rapid advances in human Mendelian genetics, electronic health record (EHR)-enabled genome–phenome associations, and genome editing.http://www.sciencedirect.com/science/article/pii/S2001037016300447High-throughput screeningWhole-organism screeningPhenotypic screeningPhenome-wide association study |
| spellingShingle | Charles H. Williams Charles C. Hong Zebrafish small molecule screens: Taking the phenotypic plunge Computational and Structural Biotechnology Journal High-throughput screening Whole-organism screening Phenotypic screening Phenome-wide association study |
| title | Zebrafish small molecule screens: Taking the phenotypic plunge |
| title_full | Zebrafish small molecule screens: Taking the phenotypic plunge |
| title_fullStr | Zebrafish small molecule screens: Taking the phenotypic plunge |
| title_full_unstemmed | Zebrafish small molecule screens: Taking the phenotypic plunge |
| title_short | Zebrafish small molecule screens: Taking the phenotypic plunge |
| title_sort | zebrafish small molecule screens taking the phenotypic plunge |
| topic | High-throughput screening Whole-organism screening Phenotypic screening Phenome-wide association study |
| url | http://www.sciencedirect.com/science/article/pii/S2001037016300447 |
| work_keys_str_mv | AT charleshwilliams zebrafishsmallmoleculescreenstakingthephenotypicplunge AT charleschong zebrafishsmallmoleculescreenstakingthephenotypicplunge |