Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression

Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression

ABSTRACT Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule are only effective against a limited number of the >100 capsular serotypes. A universal vaccine based on conserved protein antigens requires a thorough u...

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Bibliographic Details
Main Authors: Zachary N. Phillips, Claudia Trappetti, Annelies Van Den Bergh, Gael Martin, Ainslie Calcutt, Victoria Ozberk, Patrice Guillon, Manisha Pandey, Mark von Itzstein, W. Edward Swords, James C. Paton, Michael P. Jennings, John M. Atack
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
phasevarion
phase variation
Streptococcus pneumoniae
vaccine
epigenetic regulation
pneumococcus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00916-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00916-22

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