Dorsal raphe nucleus–hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice

Dorsal raphe nucleus–hippocampus serotonergic circuit underlies the depressive and cognitive impairments in 5×FAD male mice

Abstract Background Depressive symptoms often occur in patients with Alzheimer's disease (AD) and exacerbate the pathogenesis of AD. However, the neural circuit mechanisms underlying the AD-associated depression remain unclear. The serotonergic system plays crucial roles in both AD and depressi...

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Main Authors: Meiqin Chen, Chenlu Wang, Yinan Lin, Yanbing Chen, Wenting Xie, Xiaoting Huang, Fan Zhang, Congrui Fu, Kai Zhuang, Tingting Zou, Dan Can, Huifang Li, Shengxi Wu, Ceng Luo, Jie Zhang
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Depressive symptoms
Cognitive impairment
5-HT neurons
Dorsal raphe nucleus
Dorsal hippocampal CA1
Online Access:https://doi.org/10.1186/s40035-024-00425-w

Internet

https://doi.org/10.1186/s40035-024-00425-w

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