Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function.

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function.

During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize and kill invading pathogens. In Drosophila, these effectors are antimicrobial peptides (AMPs) that are produced in the fat body, an organ th...

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Bibliographic Details
Main Authors: Brittany A Martínez, Rosalie G Hoyle, Scott Yeudall, Mitchell E Granade, Thurl E Harris, J David Castle, Norbert Leitinger, Michelle L Bland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009192

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https://doi.org/10.1371/journal.pgen.1009192

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