A Novel Function of CD82/KAI1 in Sialyl Lewis Antigen-Mediated Adhesion of Cancer Cells: Evidence for an Anti-Metastasis Effect by Down-Regulation of Sialyl Lewis Antigens.

We have recently elucidated a novel function for CD82 in E-cadherin-mediated homocellular adhesion; due to this function, it can inhibit cancer cell dissociation from the primary cancer nest and limit metastasis. However, the effect of CD82 on selectin ligand-mediated heterocellular adhesion has not...

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Bibliographic Details
Main Authors: Naoya Yoshihama, Koujiro Yamaguchi, Satomi Chigita, Mariko Mine, Masakazu Abe, Kotaro Ishii, Yosuke Kobayashi, Naonari Akimoto, Yoshihide Mori, Tsuyoshi Sugiura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4414583?pdf=render