Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice

Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice

Alterations in the gut-microbiome-brain axis are increasingly being recognized to be involved in Alzheimer’s disease (AD) pathogenesis. However, the functional consequences of enteric dysbiosis linking gut microbiota and brain pathology in AD progression remain largely undetermined. The present work...

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Bibliographic Details
Main Authors: Paula M. Chilton, Smita S. Ghare, Benjamin T. Charpentier, Scott A. Myers, Aakarsha V. Rao, Joseph F. Petrosino, Kristi L. Hoffman, John C. Greenwell, Neetu Tyagi, Jyotirmaya Behera, Yali Wang, Lucy J. Sloan, JingWen Zhang, Christopher B. Shields, Gregory E. Cooper, Leila Gobejishvili, Scott R. Whittemore, Craig J. McClain, Shirish S. Barve
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes
Subjects:
Alzheimer’s disease
gut microbiome
gut dysbiosis
metagenomics
butyrate-producing bacteria
histone acetylation
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2389319

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https://www.tandfonline.com/doi/10.1080/19490976.2024.2389319

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