LPS activates neuroinflammatory pathways to induce depression in Parkinson’s disease-like condition

LPS activates neuroinflammatory pathways to induce depression in Parkinson’s disease-like condition

Aim: This study aimed to observe the effects of lipopolysaccharide (LPS) intraperitoneal (i.p.) injection on rats and investigate how neuroinflammation contributes to the pathogenesis of depression in Parkinson’s disease (dPD).Methods: Rats were administered LPS (0.5 mg/kg, i.p.) for either 1, 2, or...

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Bibliographic Details
Main Authors: Jing Zhang, Bing Xue, Bin Jing, Huiling Tian, Naiwen Zhang, Mengyuan Li, Lihua Lu, Lin Chen, Huaqiong Diao, Yufei Chen, Min Wang, Xiaoli Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
Parkinson’s disease
depression
rat model
LPS
microglia
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.961817/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.961817/full

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