Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design
Peritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a minimally invasive approach to treat PM. We aim to conduct a dose-escalation trial of mitomycin C (MMC)-PIPA...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-06-01
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| Series: | Pleura and Peritoneum |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pp-2022-0116 |
| _version_ | 1797947605239463936 |
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| author | Raoof Mustafa Sullivan Kevin M. Frankel Paul H. Fakih Marwan Synold Timothy W. Lim Dean Woo Yanghee Paz Isaac Benjamin Fong Yuman Thomas Rebecca Meera Chang Sue Eng Melissa Tinsley Raechelle Whelan Richard L. Deperalta Danielle Reymond Marc A. Jones Jeremy Merchea Amit Dellinger Thanh H. |
| author_facet | Raoof Mustafa Sullivan Kevin M. Frankel Paul H. Fakih Marwan Synold Timothy W. Lim Dean Woo Yanghee Paz Isaac Benjamin Fong Yuman Thomas Rebecca Meera Chang Sue Eng Melissa Tinsley Raechelle Whelan Richard L. Deperalta Danielle Reymond Marc A. Jones Jeremy Merchea Amit Dellinger Thanh H. |
| author_sort | Raoof Mustafa |
| collection | DOAJ |
| description | Peritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a minimally invasive approach to treat PM. We aim to conduct a dose-escalation trial of mitomycin C (MMC)-PIPAC combined with systemic chemotherapy (FOLFIRI) in patients with PM from appendiceal cancer or CRC. |
| first_indexed | 2024-04-10T21:29:31Z |
| format | Article |
| id | doaj.art-690153add2fe4855821424097e736092 |
| institution | Directory Open Access Journal |
| issn | 2364-768X |
| language | English |
| last_indexed | 2024-04-10T21:29:31Z |
| publishDate | 2022-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pleura and Peritoneum |
| spelling | doaj.art-690153add2fe4855821424097e7360922023-01-19T13:53:14ZengDe GruyterPleura and Peritoneum2364-768X2022-06-017416917710.1515/pp-2022-0116Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and designRaoof Mustafa0Sullivan Kevin M.1Frankel Paul H.2Fakih Marwan3Synold Timothy W.4Lim Dean5Woo Yanghee6Paz Isaac Benjamin7Fong Yuman8Thomas Rebecca Meera9Chang Sue10Eng Melissa11Tinsley Raechelle12Whelan Richard L.13Deperalta Danielle14Reymond Marc A.15Jones Jeremy16Merchea Amit17Dellinger Thanh H.18Department of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USADepartment of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USADepartment of Computation and Quantitative Medicine, City of Hope National Medical Center, Duarte, CA, USADepartment of Medical Oncology and Therapeutics, City of Hope National Medical Center, Duarte, CA, USAAnalytical Pharmacology Core, City of Hope Comprehensive Cancer Center, Duarte, CA, USADepartment of Medical Oncology and Therapeutics, City of Hope National Medical Center, Duarte, CA, USADepartment of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USADepartment of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USADepartment of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USADepartment of Pathology, Northwell Health, New York, NY, USADepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USAOffice of Clinical Research, City of Hope National Medical Center, Duarte, CA, USAOffice of Clinical Research, City of Hope National Medical Center, Duarte, CA, USADepartment of Surgery, Northwell Health, Donald and Barbara Zucker School of Medicine, New Hyde Park, NY, USADepartment of Surgery, Northwell Health, Donald and Barbara Zucker School of Medicine, New Hyde Park, NY, USADepartment of Surgery, University of Tuebingen, Tubingen, GermanyDepartment of Oncology (Medical), Mayo Clinic, Jacksonville, FL, USADepartment of Surgery, Mayo Clinic, Jacksonville, FL, USADepartment of Surgery, Division of Surgical Oncology, City of Hope National Medical Center, Duarte, CA, USAPeritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a minimally invasive approach to treat PM. We aim to conduct a dose-escalation trial of mitomycin C (MMC)-PIPAC combined with systemic chemotherapy (FOLFIRI) in patients with PM from appendiceal cancer or CRC.https://doi.org/10.1515/pp-2022-0116appendiceal cancercolorectal cancer (crc)mitomycin c (mmc)peritoneal metastasis (pm)phase i studypressurized intraperitoneal aerosolized chemotherapy (pipac) |
| spellingShingle | Raoof Mustafa Sullivan Kevin M. Frankel Paul H. Fakih Marwan Synold Timothy W. Lim Dean Woo Yanghee Paz Isaac Benjamin Fong Yuman Thomas Rebecca Meera Chang Sue Eng Melissa Tinsley Raechelle Whelan Richard L. Deperalta Danielle Reymond Marc A. Jones Jeremy Merchea Amit Dellinger Thanh H. Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design Pleura and Peritoneum appendiceal cancer colorectal cancer (crc) mitomycin c (mmc) peritoneal metastasis (pm) phase i study pressurized intraperitoneal aerosolized chemotherapy (pipac) |
| title | Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design |
| title_full | Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design |
| title_fullStr | Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design |
| title_full_unstemmed | Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design |
| title_short | Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design |
| title_sort | multicenter dose escalation phase i trial of mitomycin c pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases rationale and design |
| topic | appendiceal cancer colorectal cancer (crc) mitomycin c (mmc) peritoneal metastasis (pm) phase i study pressurized intraperitoneal aerosolized chemotherapy (pipac) |
| url | https://doi.org/10.1515/pp-2022-0116 |
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