Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

The rapid evolution of influenza virus makes antiviral drugs less effective, which is considered to be a major bottleneck in antiviral therapy. The key proteins in the host cells, which are related with the replication cycle of influenza virus, are regarded as potential drug targets due to their dis...

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Bibliographic Details
Main Authors: Mian Zu, Chao Li, Jian-Song Fang, Wen-Wen Lian, Ai-Lin Liu, Li-Shu Zheng, Guan-Hua Du
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Molecules
Subjects:
influenza A virus
CLK1 inhibitor
CPE assay
baculovirus coinfection
protein expression and purification
rational screening
Online Access:http://www.mdpi.com/1420-3049/20/11/19653

Internet

http://www.mdpi.com/1420-3049/20/11/19653

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