Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of anticancer treatment with doxorubicin (DOX), a very effective anthracycline widely used...

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Bibliographic Details
Main Authors: Araceli Lérida-Viso, Alejandra Estepa- Fernández, Ángela Morellá-Aucejo, Beatriz Lozano-Torres, María Alfonso, Juan F. Blandez, Viviana Bisbal, Pilar Sepúlveda, Alba García-Fernández, Mar Orzáez, Ramón Martínez-Máñez
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Pharmacological Research
Subjects:
Doxorubicin
Cardiac senescence
Senolytic
Navitoclax
Nanoparticles
Prodrug
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822003012

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http://www.sciencedirect.com/science/article/pii/S1043661822003012

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