Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Features and mechanisms of propofol-induced protein kinase C (PKC) translocation and activation in living cells

Background and purpose: In this study, we aimed to elucidate the action mechanisms of propofol, particularly those underlying propofol-induced protein kinase C (PKC) translocation.Experimental approach: Various PKCs fused with green fluorescent protein (PKC-GFP) or other GFP-fused proteins were expr...

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Bibliographic Details
Main Authors: Soma Noguchi, Taketoshi Kajimoto, Takuya Kumamoto, Masashi Shingai, Soshi Narasaki, Tomoaki Urabe, Serika Imamura, Kana Harada, Izumi Hide, Sigeru Tanaka, Yuhki Yanase, Shun-Ichi Nakamura, Yasuo M. Tsutsumi, Norio Sakai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
protein kinase C (PKC)
propofol
nuclear translocation of proteins
propofol derivatives
intracellular organelle
anesthetic
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1284586/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1284586/full

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