Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
Abstract BRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of BRAFV600E melanomas with RAF and MEK inhibitors results in rapid tumor regression. However, drug‐induced rewiring generates a drug adapted state thought to be involved in acquired resistance and dise...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2023-02-01
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| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/msb.202210988 |