A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases

A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases

Abstract Background The APOE‐ε4 allele is an established risk factor for Alzheimer's disease (AD). TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 associations with AD that are independent of APOE‐ε4 are at variance. Methods We investigated associations of A...

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Bibliographic Details
Main Authors: Selma M. Soyal, Markus Kwik, Ognian Kalev, Stefan Lenz, Greta Zara, Peter Strasser, Wolfgang Patsch, Serge Weis
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
Alzheimer’ disease
APOE
beta‐amyloid
genetics
haplotypes
neurofibrillary tangles
Online Access:https://doi.org/10.1002/mgg3.1317

Internet

https://doi.org/10.1002/mgg3.1317

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