Extensive blood transcriptome analysis reveals cellular signaling networks activated by circulating glycocalyx components reflecting vascular injury in COVID-19

Extensive blood transcriptome analysis reveals cellular signaling networks activated by circulating glycocalyx components reflecting vascular injury in COVID-19

BackgroundDegradation of the endothelial protective glycocalyx layer during COVID-19 infection leads to shedding of major glycocalyx components. These circulating proteins and their degradation products may feedback on immune and endothelial cells and activate molecular signaling cascades in COVID-1...

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Bibliographic Details
Main Authors: Melanie Borrmann, Florian Brandes, Benedikt Kirchner, Matthias Klein, Jean-Noël Billaud, Marlene Reithmair, Markus Rehm, Gustav Schelling, Michael W. Pfaffl, Agnes S. Meidert
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
small RNA
COVID-19
glycocalyx
acute respiratory distress syndrome
endothelial dysfunction
cell-free microRNAs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1129766/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1129766/full

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